Abstract

OBJECTIVE
The study was conducted to determine the bactericidal activity of a stabilized chlorine dioxide oral rinse (ClōSYS Oral Rinse) compared to products currently available on the market.
METHODS
Oral bacteria associated with gingivitis and periodontitis were exposed to rinses for one minute and five minutes. The numbers of colony forming units per milliliter (CFU/ml) were measured prior to and following exposure to determine the bactericidal activity.
RESULTS
As expected, Listerine and Crest Pro-Health demonstrated complete kill on all bacteria exposed within one minute. Breath Rx exhibited the weakest levels of bactericidal effects overall. ClōSYS and chlorhexidine rinses proved identical 100% kills against the periodontal pathogens at five minutes; in some cases, ClōSYS oral rinse achieved a higher kill at the one-minute mark over the chlorhexidine rinse.
CONCLUSION
The results demonstrated that ClōSYS Oral Rinse has potential for providing a therapeutic benefit, making it an attractive option to induce compliance in patients concerned about taste and tooth discoloration during oral health therapy.

Authors

Drake D, Villhauer AL

Institution

Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, USA. david-drake@uiowa.edu

Source

The Journal of clinical dentistry 22:1 2011 pg 1-5

MeSH

Actinobacillus actinomycetemcomitans
Actinomyces
Anti-Bacterial Agents
Anti-Infective Agents, Local
Bacterial Load
Cetylpyridinium
Chlorhexidine
Chlorine Compounds
Drug Combinations
Enterococcus faecalis
Gingivitis
Haemophilus influenzae
Humans
Klebsiella pneumoniae
Materials Testing
Mouthwashes
Oxides
Peptostreptococcus
Periodontitis
Porphyromonas gingivalis
Prevotella nigrescens
Pseudomonas aeruginosa
Salicylates
Staphylococcus aureus
Streptococcus
Streptococcus mutans
Streptococcus oralis
Terpenes
Time Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21290979