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Glutathione-S-transferase subtypes α and π as a tool to predict and monitor graft failure or regeneration in a pilot study of living donor liver transplantation.

Abstract

OBJECTIVE
Glutathione-S-transferase (GST) subtype α and π are differentially expressed in adult liver tissue. Objective of the study was if GST α and π may serve as predictive markers for liver surgery, especially transplantations.
METHODS
13 patients receiving living donor liver transplantation (LDLT) and their corresponding donors were analyzed for standard serum parameters (ALT, AST, γGT, bilirubin) as well as GST-α and -π before LDLT and daily for 10 days after LDLT. Patients (R) and donors (D) were grouped according to graft loss (R1/D1) or positive outcome (R2/D2) and above named serum parameters were compared between the groups.
RESULTS
R1 showed significantly increased GST-α and significantly lower GST-π levels than R2 patients or the donors. There was a positive correlation between GST-α and ALT, AST as well as bilirubin and a negative correlation to γGT. However, γGT correlated positively with GST-π. Graft failure was associated with combined low GST-π levels in donors and their recipients before living donor liver transplantation.
CONCLUSION
Our data suggest that high GST-α serum levels reflect ongoing liver damage while GST-π indicates the capacity and process of liver regeneration. Additionally, GST-π may be useful as marker for optimizing donor and recipient pairs in living donor liver transplantation.

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  • Authors

    Jochum C, Beste M, Sowa JP, Farahani MS, Penndorf V, Nadalin S, Saner F, Canbay A, Gerken G

    Source

    European journal of medical research 16:1 2011 Jan 27 pg 34-40

    MeSH

    Adult
    Aged
    Biological Markers
    Female
    Glutathione S-Transferase pi
    Glutathione Transferase
    Graft Survival
    Humans
    Isoenzymes
    Liver
    Liver Function Tests
    Liver Regeneration
    Liver Transplantation
    Living Donors
    Male
    Middle Aged
    Pilot Projects
    Predictive Value of Tests
    Prognosis
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21345768