Unbound MEDLINE

Thalassaemia and glucose-6-phosphate dehydrogenase deficiency in sickle-cell disorder patients in Taiz, Yemen.

Abstract

A pilot study was conducted to determine the prevalence and haematological characteristics of the interaction between thalassaemia or/and glucose-6-phosphate dehydrogenase (G6PD) deficiency in patients with sickle-cell disorder (SCD) in Taiz city, Yemen, where the prevalence of sickle-cell trait (HbAS) is 8.2%. Blood samples were collected from 31 SCD patients. Complete blood count and haemoglobin electrophoresis, G6PD activity and serum ferritin were determined. Thalassaemia was found in 6 patients (19.4%) and G6PD deficiency (6 mild and 1 severe) was detected in 7 patients (22.6%). The frequency ofthalassaemia and/or G6PD deficiency with SCD was high and this may have an effect on the severity of the clinical course of SCD in Taiz. The study should be repeated with DNA analysis to define the nature of the globin gene defect and to clarify its role in the severity of SCD

Links

  • Aggregator Full Text
  • Authors

    Al-Nood HA

    Institution

    Department of Haematology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. hafizalnood@yahoo.co.uk

    Source

    Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ 17:5 2011 May pg 404-8

    MeSH

    Adolescent
    Anemia, Sickle Cell
    Child
    Child, Preschool
    Erythrocyte Indices
    Female
    Glycogen Storage Disease Type I
    Humans
    Infant
    Male
    Pilot Projects
    Prevalence
    Thalassemia
    Yemen

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21796953