Abstract

A pilot study was conducted to determine the prevalence and haematological characteristics of the interaction between thalassaemia or/and glucose-6-phosphate dehydrogenase (G6PD) deficiency in patients with sickle-cell disorder (SCD) in Taiz city, Yemen, where the prevalence of sickle-cell trait (HbAS) is 8.2%. Blood samples were collected from 31 SCD patients. Complete blood count and haemoglobin electrophoresis, G6PD activity and serum ferritin were determined. Thalassaemia was found in 6 patients (19.4%) and G6PD deficiency (6 mild and 1 severe) was detected in 7 patients (22.6%). The frequency ofthalassaemia and/or G6PD deficiency with SCD was high and this may have an effect on the severity of the clinical course of SCD in Taiz. The study should be repeated with DNA analysis to define the nature of the globin gene defect and to clarify its role in the severity of SCD

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Authors

Al-Nood HA

Institution

Department of Haematology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. hafizalnood@yahoo.co.uk

Source

Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ 17:5 2011 May pg 404-8

MeSH

Adolescent
Anemia, Sickle Cell
Child
Child, Preschool
Erythrocyte Indices
Female
Glycogen Storage Disease Type I
Humans
Infant
Male
Pilot Projects
Prevalence
Thalassemia
Yemen

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21796953