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A facile, viable approach toward the preparation of 32p patches for the treatment of skin cancer.

Abstract

A facile, viable, "green" two-step, inexpensive technique was developed for the preparation of (32)P patch for the treatment of skin cancer. This technique consists of impregnation of H(3)(32)PO(4) solution into an inert solid carrier followed by immobilization into a nonleachable matrix by lamination. The morphology of the impregnated paper was evaluated by scanning electron microscope and energy-dispersive spectral analyses. Radioactive patches containing up to ∼37 MBq/cm(2) of (32)P could be prepared. Distribution of (32)P on sources was uniform and release of (32)P from the sealed source in water and saline was found to be well within the permissible levels of 185 Bq. Custom-shaped (32)P-patches after quality assurance were supplied to AIIMS, New Delhi, for clinical evaluation. (32)P-impregnated paper protected by a laminated film holds promise for treatment of superficial cancers.

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  • Authors

    Saxena SK, Kumar Y, Pandey U, Shinde SN, Muthe KP, Venkatesh M, Dash A

    Institution

    Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India.

    Source

    Cancer biotherapy & radiopharmaceuticals 26:5 2011 Oct pg 665-70

    MeSH

    Administration, Cutaneous
    Animals
    Autoradiography
    Brachytherapy
    Drug Delivery Systems
    Humans
    Mice
    Mice, Inbred C57BL
    Phosphorus Radioisotopes
    Skin Neoplasms
    Transdermal Patch

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21834650