A facile, viable approach toward the preparation of 32p patches for the treatment of skin cancer.

Abstract

A facile, viable, "green" two-step, inexpensive technique was developed for the preparation of (32)P patch for the treatment of skin cancer. This technique consists of impregnation of H(3)(32)PO(4) solution into an inert solid carrier followed by immobilization into a nonleachable matrix by lamination. The morphology of the impregnated paper was evaluated by scanning electron microscope and energy-dispersive spectral analyses. Radioactive patches containing up to ∼37 MBq/cm(2) of (32)P could be prepared. Distribution of (32)P on sources was uniform and release of (32)P from the sealed source in water and saline was found to be well within the permissible levels of 185 Bq. Custom-shaped (32)P-patches after quality assurance were supplied to AIIMS, New Delhi, for clinical evaluation. (32)P-impregnated paper protected by a laminated film holds promise for treatment of superficial cancers.

Links

Publisher Full Text

Authors

Saxena SK, Kumar Y, Pandey U, Shinde SN, Muthe KP, Venkatesh M, Dash A

Institution

Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India.

Source

Cancer biotherapy & radiopharmaceuticals 26:5 2011 Oct pg 665-70

MeSH

Administration, Cutaneous
Animals
Autoradiography
Brachytherapy
Drug Delivery Systems
Humans
Mice
Mice, Inbred C57BL
Phosphorus Radioisotopes
Skin Neoplasms
Transdermal Patch

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21834650