Unbound MEDLINE

Fragrance material review on 3-phenylpropyl cinnamate.

Abstract

A toxicologic and dermatologic review of 3-phenylpropyl cinnamate when used as a fragrance ingredient is presented. 3-Phenylpropyl cinnamate is a member of the fragrance structural group cinnamyl phenylpropyl compounds. The common characteristic structural element of cinnamyl phenylpropyl materials is an aryl substituted primary alcohol/aldehyde/ester. They are simple aromatic compounds with saturated propyl or unsaturated propenyl side chains containing a primary oxygenated functional group which has little toxic potential. 3-Phenyl-1-propyl derivatives participate in the same beta-oxidation pathways as do their parent cinnamic acid derivatives. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 3-phenylpropyl cinnamate was evaluated then summarized and includes physical properties, acute toxicity, skin irritation and skin sensitization. A safety assessment of all cinnamyl phenylpropyl compounds will be published simultaneously with this document. Please refer to Belsito et al. (2011) for an overall assessment of the safe use of this material and all the cinnamyl phenylpropyl materials in fragrances. Belsito, D., Bickers, D., Bruze, M., Dagli, M.L., Fryer, A., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of cinnamyl phenylpropyl compounds when used as fragrance ingredients.

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  • Publisher Full Text
  • Authors

    Bhatia SP, Cocchiara J, Wellington GA, Lalko J, Letizia CS, Api AM

    Source

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 49 Suppl 2: 2011 Dec pg S252-5

    MeSH

    Animals
    Cinnamates
    DNA Damage
    Dermatitis, Allergic Contact
    Dermatitis, Phototoxic
    Eye Injuries
    Humans
    Mucous Membrane
    Odors
    Pentanols
    Perfume
    Skin
    Toxicity Tests

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21855596