Unbound MEDLINE

Clinical pleiomorphism in human leishmaniases, with special mention of asymptomatic infection.

Abstract

This review gives an update of current knowledge on the clinical pleiomorphism of Leishmania, with a special emphasis on the case of asymptomatic carriage. The first part describes the numerous unusual expressions of the disease that occur besides the classic (visceral, cutaneous, and mucocutaneous) forms of leishmaniases. The second part deals with progress in the understanding of disease outcome in humans, and the possible future approaches to improve our knowledge in the field. The third part highlights the role of the too often neglected asymptomatic carrier compartment. This group could be key to understanding infraspecific differences in virulence and pathogenicity of the parasite, as well as identifying the genetic determinants involved in the expression of the disease.

Links

  • Publisher Full Text
  • Authors

    Bañuls AL, Bastien P, Pomares C, Arevalo J, Fisa R, Hide M

    Source

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 17:10 2011 Oct pg 1451-61

    MeSH

    Animals
    Asymptomatic Infections
    Coinfection
    Disease Reservoirs
    Disease Vectors
    Dogs
    Gene Expression Regulation
    Geography
    Host-Pathogen Interactions
    Humans
    Immune Evasion
    Immunity, Cellular
    Leishmania
    Leishmaniasis
    Mammals
    Psychodidae
    Species Specificity
    Virulence

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    21933304