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Virilizing ovarian stromal tumor in a young woman with Carney complex.

Abstract

A woman with Carney complex presented at the age of 22 years with abdominal pain and hirsutism. As a baby, she had undergone excision of a right eyelid lesion, and at age 14 years she had undergone removal of a left lower eyelid nodule that subsequently recurred. Investigation revealed an elevated level of serum testosterone and a 2-cm left ovarian tumor. A left salpingo-oophorectomy was performed. Postoperatively, she experienced relief from abdominal pain, the serum level of testosterone normalized, and the hirsutism ameliorated. The tumor featured sheets of eosinophilic cells with lipochrome pigment, myeloid metaplasia, stromal metaplasia, and markedly abnormal blood vessels. Immunocytochemically, the tumor cells were positive for vimentin, synaptophysin, inhibin-A, and calrenin. Because of the clinical setting in which the neoplasm occurred, it is likely that is occurrence was related to Carney complex.

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  • Authors

    Carney JA, Stratakis CA

    Source

    The American journal of surgical pathology 35:10 2011 Oct pg 1592-9

    MeSH

    Calbindin 2
    Carney Complex
    Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
    DNA Mutational Analysis
    Female
    Humans
    Inhibins
    Leydig Cell Tumor
    Ovarian Neoplasms
    Ovariectomy
    S100 Calcium Binding Protein G
    Stromal Cells
    Synaptophysin
    Testosterone
    Tumor Markers, Biological
    Vimentin
    Virilism

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    21934476