Abstract

A woman with Carney complex presented at the age of 22 years with abdominal pain and hirsutism. As a baby, she had undergone excision of a right eyelid lesion, and at age 14 years she had undergone removal of a left lower eyelid nodule that subsequently recurred. Investigation revealed an elevated level of serum testosterone and a 2-cm left ovarian tumor. A left salpingo-oophorectomy was performed. Postoperatively, she experienced relief from abdominal pain, the serum level of testosterone normalized, and the hirsutism ameliorated. The tumor featured sheets of eosinophilic cells with lipochrome pigment, myeloid metaplasia, stromal metaplasia, and markedly abnormal blood vessels. Immunocytochemically, the tumor cells were positive for vimentin, synaptophysin, inhibin-A, and calrenin. Because of the clinical setting in which the neoplasm occurred, it is likely that is occurrence was related to Carney complex.

Links

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Publisher Full Text

Authors

Carney JA, Stratakis CA

Institution

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. carney.aidan@mayo.edu

Source

The American journal of surgical pathology 35:10 2011 Oct pg 1592-9

MeSH

Calcium-Binding Protein, Vitamin D-Dependent
Carney Complex
Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
DNA Mutational Analysis
Female
Humans
Inhibins
Leydig Cell Tumor
Ovarian Neoplasms
Ovariectomy
Stromal Cells
Synaptophysin
Testosterone
Tumor Markers, Biological
Vimentin
Virilism

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

21934476