Abstract

PURPOSE
To establish camera-based methods for estimating Tc-99m mercaptoacetyltriglycine (MAG3) clearance without blood sampling.
MATERIALS AND METHODS
The results of renal scintigraphy with Tc-99m MAG3 obtained from 160 patients were analyzed retrospectively. Eight renogram parameters were calculated for each patient based on the area under the renogram (area method) and slope of the renogram (slope method) using different periods for analysis (1-2 and 1-2.5 minutes for the area method; 0.5-1.5 and 0.5-2 minutes for the slope method) and different backgrounds for subtraction (perirenal and subrenal backgrounds). The 8 parameters were then correlated with MAG3 clearance measured by the single-sample methods proposed by Russell et al and Bubeck et al to determine the equation for the conversion of renogram parameters to clearance.
RESULTS
All 8 renogram parameters were highly correlated with clearance measured by the single-sample methods, and the obtained equations enabled the estimation of clearance from image data. Selection between the area and slope methods, between different periods for analysis, or between perirenal and subrenal backgrounds did not cause large differences in the estimation.
CONCLUSION
The camera-based methods determined in the present study allow the estimation of MAG3 clearance with acceptable accuracy.

Links

Publisher Full Text

Authors

Inoue Y, Ohtomo K

Institution

Department of Diagnostic Radiology, Kitasato University School of Medicine, Sagamihara, Japan. inoueys34@gmail.com

Source

Clinical nuclear medicine 36:11 2011 Nov pg 1012-6

MeSH

Adolescent
Adult
Aged
Aged, 80 and over
Blood Specimen Collection
Female
Gamma Cameras
Humans
Kidney
Male
Middle Aged
Radioisotope Renography
Technetium Tc 99m Mertiatide
Young Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21975390