Unbound MEDLINE

Cerebral thrombosis complicating Crohn's disease: two cases.

Abstract

Cerebrovenous thrombosis is quite rare in infammatory bowel disease. There are only a few reports of this association in the literature. We report 2 cases of patients with Crohn's disease (CD) who developed cerebral thrombophlebitis confirmed by neuroimaging. The first case was a 35-year-old man with a history of CD who presented with acute confusion. Brain magnetic resonance imaging demonstrated a left temporoparietal infarction and thrombosis of the left lateral sinus. Coagulation studies showed a marked protein S deficiency. His condition improved significantly after initiation of anticoagulant therapy. The second case was a 38-year-old woman who was admitted for a sudden loss of consciousness with tetraplegia. Brain computed tomography revealed a profound cerebrovenous thrombosis. She died within a few days after admission. Inflammatory bowel disease carries an increased risk of venous and arterial thrombosis. Although the pathogenic mechanisms of this predisposition are unclear, a possible role of inherited risk factors for thrombosis in determining this predisposition has been suggested. In these cases, both fibrinolysis and coagulation are activated as well.

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  • Publisher Full Text
  • Authors

    Benjilali L, Aidi S, El Mansouri H, Benabdejlil M, Jiddane M, El Alaoui Faris M

    Source

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20:6 2011 Nov pg 565-9

    MeSH

    Adult
    Anticoagulants
    Cerebral Angiography
    Confusion
    Crohn Disease
    Fatal Outcome
    Female
    Humans
    Intracranial Thrombosis
    Magnetic Resonance Angiography
    Male
    Phlebography
    Protein S Deficiency
    Quadriplegia
    Thrombophlebitis
    Tomography, X-Ray Computed
    Treatment Outcome
    Unconsciousness

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    22078296