Unbound MEDLINE

Radiation fibrosis syndrome: neuromuscular and musculoskeletal complications in cancer survivors.

Abstract

Radiation-induced toxicity is a major cause of long-term disability after cancer treatment. Radiation fibrosis describes the insidious pathologic fibrotic tissue sclerosis that can occur in response to radiation exposure. Radiation fibrosis syndrome describes the myriad clinical manifestations of progressive fibrotic tissue sclerosis resulting from radiation treatment. Radiation-induced damage can include "myelo-radiculo-plexo-neuro-myopathy," causing muscle weakness and dysfunction and contributing to neuromuscular injury. Similarly, radiation damage to neuromuscular structures contributes to radiation-induced trismus and cervical dystonia in head and neck cancer survivors. This narrative review discusses the pathophysiology, anatomy, evaluation, and treatment of neuromuscular, musculoskeletal, and functional disorders that can result as late effects of radiation treatment. Rehabilitation medicine physicians with extensive training in neuromuscular and musculoskeletal medicine as well as in the principles of functional restoration are uniquely positioned to help lead efforts to improve the quality of life for cancer survivors with radiation fibrosis syndrome.

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  • Publisher Full Text
  • Authors

    Stubblefield MD

    Source

    PM & R : the journal of injury, function, and rehabilitation 3:11 2011 Nov pg 1041-54

    MeSH

    Disability Evaluation
    Fibrosis
    Humans
    Musculoskeletal Diseases
    Neoplasms
    Neuromuscular Diseases
    Radiation Injuries
    Risk Factors
    Syndrome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    22108231