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Topical application of tacrolimus prevents epidural fibrosis in a rat postlaminectomy model: histopathological and ultrastructural analysis.

Abstract

AIM
Postlaminectomy epidural fibrosis is the formation of scar tissue over the dura mater following posterior spinal surgery. This devastating complication is responsible for the substantial amount of failed back syndromes. MATERIAL and
METHODS
Twenty male Wistar-Albino rats each weighing 350-400 grams were used. Following L3-L5 laminectomy, the rats were randomly divided into 2 groups, with 10 rats in each group. In the control group, only a laminectomy was performed. In the drug group, 5 mg/ml tacrolimus was topically applied with a cotton pad soaked with the drug solution for 5 minutes. The animals were killed on the 30th postoperative day injecting a lethal dose (250 mg/kg) of pentobarbital and the involved dural segments were removed for histopathological and ultrastructural evaluations.
RESULTS
Epidural scar thickness and the density were significantly lower in the animals treated with tacrolimus than those of the control group.
CONCLUSION
Promising evidence regarding the anti-scar potential of tacrolimus merits further research to optimize the dosage and the usage of the drug.

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  • Authors

    Ismailoglu O, Albayrak B, Gulsen I, Tanriover G, Demir N

    Source

    Turkish neurosurgery 21:4 2011 pg 630-3

    MeSH

    Administration, Topical
    Animals
    Cell Movement
    Cicatrix
    Disease Models, Animal
    Dura Mater
    Epidural Space
    Failed Back Surgery Syndrome
    Fibroblasts
    Fibrosis
    Immunosuppressive Agents
    Laminectomy
    Lumbar Vertebrae
    Male
    Microscopy, Electron
    Neurosurgical Procedures
    Postoperative Complications
    Rats
    Rats, Wistar
    Spinal Canal
    Tacrolimus
    Treatment Outcome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22194127