Abstract

There is no current cure for Duchenne muscular dystrophy (DMD), and palliative and prophylactic interventions to improve the quality of life of patients remain limited, with the exception of corticosteroids. This article describes 2 potential nutritional interventions for the treatment of DMD, green tea extract (GTE) and the branched-chain amino acid leucine, and their positive effects on physical activity. Both GTE and leucine are suitable for human consumption, are easily tolerated with no side effects, and, with appropriate preclinical data, could be brought forward to clinical trials rapidly.

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Publisher Full Text

Publisher Full Text

Authors

Davoodi J, Markert CD, Voelker KA, Hutson SM, Grange RW

Institution

Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, VA 24061, USA.

Source

Physical medicine and rehabilitation clinics of North America 23:1 2012 Feb pg 187-99, xii-xiii

MeSH

Animals
Camellia sinensis
Dietary Supplements
Humans
Leucine
Motor Activity
Muscular Dystrophy, Duchenne
Phytotherapy
Plant Extracts
Signal Transduction
TOR Serine-Threonine Kinases

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22239883