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Frequency of juvenile fibromyalgia syndrome in children with familial Mediterranean fever: effects on depression and quality of life.

Abstract

OBJECTIVES
To determine the prevalence of juvenile fibromyalgia syndrome (JFMS) in children with familial Mediterranean fever (FMF) and to evaluate quality of life (QoL) and depression.
METHODS
Ninety-one FMF patients (M/F: 44/47) who fulfilled the Livneh criteria and 60 healthy children (M/F: 27/33) were enrolled in the study. Yunus and Masi's criteria were used for diagnosis of JFMS. Depression was assessed with Children's Depression Inventory (CDI) and QoL was evaluated with child and parent reports of Paediatric Quality of Life Inventory 4.0 (PedsQL™).
RESULTS
While 20 (21.9%) of 91 FMF patients fulfilled JFMS criteria, 2 (3.3%) of the control group met the diagnostic criteria of JFMS (p=0.002). PedsQL™ scores (child self-report and parent-report) of the FMF patients were significantly lower and the depression scores were significantly higher than the healthy controls (p<0.001 for all). When the FMF patients were assigned to two groups as FMF with or without JFMS, patients with JFMS were found to have a higher depression score (p=0.007) and child and parent reports of PedsQL™ 4.0 were lower in the children with JFMS than in the patients without JFMS (p=0.001, p=0.003, respectively).
CONCLUSIONS
We have determined that JFMS frequency was higher in children with FMF and patients with FMF and JFMS had a poor QoL and were more susceptible to depression. FMF patients with widespread and persistent pain should be evaluated for JFMS in order to avoid unnecessary investigations and inappropriate treatment.

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  • Publisher Full Text

    • Authors

    Alayli G, Durmus D, Ozkaya O, Sen HE, Genc G, Kuru O

    Institution

    Department of Physical Medicine and Rehabilitation, Ondokuz Mayis University, Medical Faculty, Samsun, Turkey. alayli70@yahoo.com

    Source

    Clinical and experimental rheumatology 29:6 Suppl 69 pg S127-32

    MeSH

    Adolescent
    Age of Onset
    Child
    Chronic Pain
    Comorbidity
    Depression
    Familial Mediterranean Fever
    Family Health
    Female
    Fibromyalgia
    Humans
    Male
    Prevalence
    Quality of Life
    Severity of Illness Index
    Syndrome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22243560