Unbound MEDLINE

Maternal asthma medication use and the risk of selected birth defects.

Abstract

OBJECTIVES
Approximately 4% to 12% of pregnant women have asthma; few studies have examined the effects of maternal asthma medication use on birth defects. We examined whether maternal asthma medication use during early pregnancy increased the risk of selected birth defects.
METHODS
National Birth Defects Prevention Study data for 2853 infants with 1 or more selected birth defects (diaphragmatic hernia, esophageal atresia, small intestinal atresia, anorectal atresia, neural tube defects, omphalocele, or limb deficiencies) and 6726 unaffected control infants delivered from October 1997 through December 2005 were analyzed. Mothers of cases and controls provided telephone interviews of medication use and additional potential risk factors. Exposure was defined as maternal periconceptional (1 month prior through the third month of pregnancy) asthma medication use (bronchodilator or anti-inflammatory). Associations between maternal periconceptional asthma medication use and individual major birth defects were estimated by using adjusted odds ratios (aOR) and 95% confidence intervals (95%CI).
RESULTS
No statistically significant associations were observed for maternal periconceptional asthma medication use and most defects studied; however, positive associations were observed between maternal asthma medication use and isolated esophageal atresia (bronchodilator use: aOR = 2.39, 95%CI = 1.23, 4.66), isolated anorectal atresia (anti-inflammatory use: aOR = 2.12, 95%CI = 1.09, 4.12), and omphalocele (bronchodilator and anti-inflammatory use: aOR = 4.13, 95%CI = 1.43, 11.95).
CONCLUSIONS
Positive associations were observed for anorectal atresia, esophageal atresia, and omphalocele and maternal periconceptional asthma medication use, but not for other defects studied. It is possible that observed associations may be chance findings or may be a result of maternal asthma severity and related hypoxia rather than medication use.

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  • Publisher Full Text
  • Authors

    Lin S, Munsie JP, Herdt-Losavio ML, Druschel CM, Campbell K, Browne ML, Romitti PA, Olney RS, Bell EM, National Birth Defects Prevention Study

    Institution

    Center for Environmental Health, New York State Department of Health, Troy, NY, USA.

    Source

    Pediatrics 129:2 2012 Feb pg e317-24

    MeSH

    Abnormalities, Drug-Induced
    Adult
    Albuterol
    Anal Canal
    Androstadienes
    Anti-Asthmatic Agents
    Anti-Inflammatory Agents
    Anus, Imperforate
    Asthma
    Beclomethasone
    Bronchodilator Agents
    Case-Control Studies
    Esophagus
    Female
    Heart Defects, Congenital
    Humans
    Kidney
    Limb Deformities, Congenital
    Male
    Middle Aged
    Pregnancy
    Pregnancy Complications
    Pregnancy Trimester, First
    Radius
    Risk Factors
    Spine
    Trachea
    United States
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    22250027