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Effect of iron deficiency anemia on hemoglobin A1c levels.

Abstract

BACKGROUND
Iron deficiency anemia is the most common form of anemia in India. Hemoglobin A1c (HbA1c) is used in diabetic patients as an index of glycemic control reflecting glucose levels of the previous 3 months. Like blood sugar levels, HbA1c levels are also affected by the presence of variant hemoglobins, hemolytic anemias, nutritional anemias, uremia, pregnancy, and acute blood loss. However, reports on the effects of iron deficiency anemia on HbA1c levels are inconsistent. We conducted a study to analyze the effects of iron deficiency anemia on HbA1c levels and to assess whether treatment of iron deficiency anemia affects HbA1c levels.
METHODS
Fifty patients confirmed to have iron deficiency anemia were enrolled in this study. HbA1c and absolute HbA1c levels were measured both at baseline and at 2 months after treatment, and these values were compared with those in the control population.
RESULTS
The mean baseline HbA1c level in anemic patients (4.6%) was significantly lower than that in the control group (5.5%, P<0.05). A significant increase was observed in the patients' absolute HbA1c levels at 2 months after treatment (0.29 g/dL vs. 0.73 g/dL, P<0.01). There was a significant difference between the baseline values of patients and controls (0.29 g/dL vs. 0.74 g/dL, P<0.01).
CONCLUSIONS
In contrast to the observations of previous studies, ours showed that HbA1c levels and absolute HbA1c levels increased with treatment of iron deficiency anemia. This could be attributable to nutritional deficiency and/or certain unknown variables. Further studies are warranted.

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  • Authors

    Sinha N, Mishra TK, Singh T, Gupta N

    Source

    Annals of laboratory medicine 32:1 2012 Jan pg 17-22

    MeSH

    Adolescent
    Adult
    Anemia, Iron-Deficiency
    Child
    Female
    Ferritins
    Hemoglobin A, Glycosylated
    Hemoglobins
    Humans
    Iron
    Male
    Time Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22259774