Abstract

PURPOSE
To assess lymph node invasion through the use of sentinel lymph node biopsy (SLNB) in conjunctival and eyelid tumor patients and ascertain the impact of this technique in therapeutic management recommended by the multidisciplinary consensus committee.
METHODS
A single center prospective nonrandomized clinical study was conducted between January 2008 and January 2010. Seventeen patients were included: 4 (2 conjunctiva and 2 eyelid) melanomas, 4 eyelid Merkel cell tumors, 8 (2 conjunctiva, 2 eyelid, 2 eyelid and conjunctiva, 2 cornea and conjunctiva) squamous cell tumors, and 1 eyelid meibomian carcinoma. Preoperative lymphoscintigraphy was done the day before surgery to label lymph node(s). The surgical biopsy was then performed along with an extemporaneous pathological examination followed by secondary complete lymph node dissection only in instances of positive histology.
RESULTS
In all cases, one or more sentinel lymph nodes were identified (3-13). Two biopsies (1 Merkel cell carcinoma and 1 squamous cell carcinoma) revealed neoplastic invasion and led to complete cervical node dissection. Adjunct regional treatment was indicated for 1 melanoma, for 4 Merkel cell tumors, and for 2 squamous cell carcinomas. One false negative result was noted in the group of squamous cell carcinomas after 6 months, and it was treated. No relapse or death was observed for the other 16 patients. The mean overall follow-up was 18.2 months.
CONCLUSION
As in previous studies, we found that SLNB for eyelid and conjunctival tumors is safe and effective in identifying microscopically positive SLNs. This procedure may also revive interest in the study of cervicofacial lymphatic drainage. Our current investigation is to be expanded and extended to other medical teams.

Links

Publisher Full Text

Authors

Maalouf TJ, Dolivet G, Angioi KS, Leroux A, Genin P, George JL

Institution

Department of Oculoplastic Surgery, Ophtalmologie B, CHU Nancy-Brabois, Nancy, France. t.maalouf@chu-nancy.fr

Source

Ophthalmic plastic and reconstructive surgery 28:1 2012 Jan pg 30-4

MeSH

Aged
Aged, 80 and over
Carcinoma
Conjunctival Neoplasms
Eyelid Neoplasms
Female
Humans
Lymph Nodes
Male
Melanoma
Middle Aged
Neoplasm Invasiveness
Prospective Studies
Sentinel Lymph Node Biopsy

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22262287