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Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women.

Abstract

OBJECTIVE
To study the risk for obstructive sleep apnea (OSA) in a group of nonobese and obese polycystic ovary syndrome (PCOS) and control women.
DESIGN
Prospective study.
SETTING
Academic tertiary care medical center.
PATIENT(S)
Forty-four women with PCOS and 34 control women.
INTERVENTION(S)
All of the women completed the Berlin questionnaire for assessment of OSA risk.
MAIN OUTCOME MEASURE(S)
All of the women underwent fasting determination of androgens, glucose, and insulin.
RESULT(S)
Women with PCOS were more obese compared with control women. However, there were no differences in BMI once subjects were divided into nonobese (PCOS: n = 17; control: n = 26) and obese (PCOS: n = 27; control: n = 8) groups. Women with PCOS had higher prevalence of high-risk OSA compared with control women (47% vs. 15%). However, none of the nonobese PCOS and control women screened positively for high-risk OSA. Among the obese group, the risk did not differ between groups (77% vs. 63%).
CONCLUSION(S)
Our findings indicate that even though the risk for OSA in PCOS is high, it is related to the high prevalence of severe obesity. The risk for OSA among nonobese women with PCOS is very low. However, our findings are limited by lack of polysomnographic confirmation of OSA.

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  • Authors

    Mokhlesi B, Scoccia B, Mazzone T, Sam S

    Institution

    Sleep Disorders Center, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60612, USA.

    Source

    Fertility and sterility 97:3 2012 Mar pg 786-91

    MeSH

    Academic Medical Centers
    Adult
    Biological Markers
    Blood Glucose
    Body Mass Index
    Case-Control Studies
    Chicago
    Female
    Humans
    Insulin
    Insulin Resistance
    Obesity
    Polycystic Ovary Syndrome
    Prevalence
    Prospective Studies
    Questionnaires
    Reproduction
    Risk Assessment
    Risk Factors
    Sleep Apnea, Obstructive
    Testosterone
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22264851