Abstract

OBJECTIVE
To study the risk for obstructive sleep apnea (OSA) in a group of nonobese and obese polycystic ovary syndrome (PCOS) and control women.
DESIGN
Prospective study.
SETTING
Academic tertiary care medical center.
PATIENT(S)
Forty-four women with PCOS and 34 control women.
INTERVENTION(S)
All of the women completed the Berlin questionnaire for assessment of OSA risk.
MAIN OUTCOME MEASURE(S)
All of the women underwent fasting determination of androgens, glucose, and insulin.
RESULT(S)
Women with PCOS were more obese compared with control women. However, there were no differences in BMI once subjects were divided into nonobese (PCOS: n = 17; control: n = 26) and obese (PCOS: n = 27; control: n = 8) groups. Women with PCOS had higher prevalence of high-risk OSA compared with control women (47% vs. 15%). However, none of the nonobese PCOS and control women screened positively for high-risk OSA. Among the obese group, the risk did not differ between groups (77% vs. 63%).
CONCLUSION(S)
Our findings indicate that even though the risk for OSA in PCOS is high, it is related to the high prevalence of severe obesity. The risk for OSA among nonobese women with PCOS is very low. However, our findings are limited by lack of polysomnographic confirmation of OSA.

Links

PMC Free PDF

Publisher Full Text

Authors

Mokhlesi B, Scoccia B, Mazzone T, Sam S

Institution

Sleep Disorders Center, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60612, USA.

Source

Fertility and sterility 97:3 2012 Mar pg 786-91

MeSH

Academic Medical Centers
Adult
Biological Markers
Blood Glucose
Body Mass Index
Case-Control Studies
Chicago
Female
Humans
Insulin
Insulin Resistance
Obesity
Polycystic Ovary Syndrome
Prevalence
Prospective Studies
Questionnaires
Reproduction
Risk Assessment
Risk Factors
Sleep Apnea, Obstructive
Testosterone
Young Adult

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22264851