Unbound MEDLINE

A controlled clinical exploratory study on genetic markers for peri-implantitis.

Abstract

PURPOSE
The objective of this controlled exploratory cross-sectional study was to investigate and compare the presence of gene expression of bone resorption/remodelling in peri-implant crevicular fluid samples from healthy subjects and subjects showing obvious clinical and radiographic signs of peri-implantitis.
MATERIALS AND METHODS
Peri-implant crevicular fluid (PICF) was sampled from seven healthy subjects and seven subjects with obvious clinical signs of peri-implantitis using paper points. The samples were analysed by quantitative polymerase chain reaction (qPCR). Biomarkers associated with bone degradation/remodelling, such as tartrate-resistant acid phosphatase (TRAP), dickkopf-related protein- 1 (DKK-1), osteoprotegerin (OPG), cathepsin K (CatK) and osteocalcin (OC), were of particular interest in the study.
RESULTS
The measured levels of genetic markers were similar for the subjects in the healthy and the peri-implantitis group. Only one subject out of seven with strong and clear clinical signs of peri-implantitis exhibited a panel of genetic markers for ongoing bone degradation. This subject was also diagnosed with rheumatoid arthritis.
CONCLUSION
The present data showed that patients with obvious clinical signs of peri-implantitis and a history of bone loss can exhibit similar gene expressions of bone loss/remodelling as clinically healthy implant patients. Absence of bone resorption markers demonstrated that it was not possible to establish ongoing bone degradation in six of seven subjects in the peri-implantitis group. The results suggest that bone resorption was not in progress at the time of PICF sampling, or that cells expressing such markers were not present in significant numbers at the site of PICF sampling.

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  • Authors

    Hall J, Britse AO, Jemt T, Friberg B

    Institution

    Nobel Biocare, Goteborg, Sweden. jan.hall@nobelbiocare.com

    Source

    European journal of oral implantology 4:4 2011 pg 371-82

    MeSH

    Acid Phosphatase
    Aged
    Alkaline Phosphatase
    Biological Markers
    Bone Remodeling
    Bone Resorption
    Cathepsin K
    Cross-Sectional Studies
    Dental Implants
    Feasibility Studies
    Female
    Genetic Markers
    Gingival Crevicular Fluid
    Humans
    Intercellular Signaling Peptides and Proteins
    Interleukin-1beta
    Isoenzymes
    Male
    Osteocalcin
    Osteoprotegerin
    Peri-Implantitis
    RANK Ligand
    Real-Time Polymerase Chain Reaction
    Single-Blind Method
    Tumor Necrosis Factor-alpha

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22282733