Abstract

Several equations have been used to predict lung function standard results for different populations. It is important lung function evaluations use appropriate standards for the study population. The objective of this study was to develop a prediction equation for lung function test results for the Malaysian population. Spirometry was performed among 5,708 subjects and 1,483 healthy, lifetime never smoked subjects (386 males and 1,097 females). Prediction equations were derived for both men and women for FVC and FEV1 results. The equations were validated on new subjects (n = 532, 222 males and 310 females) who met the same inclusion and exclusion criteria as the main cohort. There was a positive correlation between the measured values and the values derived from the new prediction equations (0.62 for FEV1 and between 0.66 and 0.67 for FVC; both p < 0.05) for both men and women with a smaller bias and limit of agreement compared to the published reference equations of ECCS, Knudson, Crapo and NHANES III. The reference equations derived from local spirometry data were more appropriate than generally used equations based on data from previous studies in different population.

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Authors

Gnanou J, Caszo B, Mohamad WH, Nawawi H, Yusoff K, Ismail T

Institution

Faculty of Medicine, Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia. gnanou_j@yahoo.com

Source

The Southeast Asian journal of tropical medicine and public health 42:4 2011 Jul pg 965-76

MeSH

Adult
Age Factors
Aged
Aged, 80 and over
Asian Continental Ancestry Group
Body Height
Female
Humans
Lung
Malaysia
Male
Middle Aged
Reference Values
Regression Analysis
Respiratory Function Tests
Sex Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22299480