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Prediction equations for lung function in healthy, life time never-smoking Malaysian population.

Abstract

Several equations have been used to predict lung function standard results for different populations. It is important lung function evaluations use appropriate standards for the study population. The objective of this study was to develop a prediction equation for lung function test results for the Malaysian population. Spirometry was performed among 5,708 subjects and 1,483 healthy, lifetime never smoked subjects (386 males and 1,097 females). Prediction equations were derived for both men and women for FVC and FEV1 results. The equations were validated on new subjects (n = 532, 222 males and 310 females) who met the same inclusion and exclusion criteria as the main cohort. There was a positive correlation between the measured values and the values derived from the new prediction equations (0.62 for FEV1 and between 0.66 and 0.67 for FVC; both p < 0.05) for both men and women with a smaller bias and limit of agreement compared to the published reference equations of ECCS, Knudson, Crapo and NHANES III. The reference equations derived from local spirometry data were more appropriate than generally used equations based on data from previous studies in different population.

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  • Authors

    Gnanou J, Caszo B, Mohamad WH, Nawawi H, Yusoff K, Ismail T

    Source

    The Southeast Asian journal of tropical medicine and public health 42:4 2011 Jul pg 965-76

    MeSH

    Adult
    Age Factors
    Aged
    Aged, 80 and over
    Asian Continental Ancestry Group
    Body Height
    Female
    Humans
    Lung
    Malaysia
    Male
    Middle Aged
    Reference Values
    Regression Analysis
    Respiratory Function Tests
    Sex Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22299480