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Effect of PVA on the gel temperature of MC and release kinetics of KT from MC based ophthalmic formulations.

Abstract

The effect of molecular weight of poly(vinyl alcohol) (PVA) and sodium chloride on the gelation temperature of methylcellulose (MC) was studied with the objective to develop a MC based formulation for sustained delivery of ketorolac tromethamine a model ophthalmic drug. Pure MC showed sol-gel transition at 61.2 °C. In order to reduce the gelation temperature of MC and to increase the drug release time, PVA was used. Different techniques such as test tube tilting method, UV-vis spectroscopy, viscometry and rheometry were used to measure gelation temperature of all the binary combinations of MC and PVA. It was observed that the gelation temperature of MC was reduced with the addition of 4% PVA and also the extent of reduction of the gelation temperature of MC was dependent on the molecular weight of PVA. The strong interactions between MC and PVA molecules were established using Fourier transform infrared spectroscopy. To study the in vitro drug release properties of the MC-PVA binary combinations, 6% sodium chloride was used to reduce the gelation temperature further up to physiological temperature. It was observed that the drug release time increased from 5 to 8h with the increase of molecular weight of PVA from 9×10(3) to 1.3×10(5) and this was due to the higher viscosity, better gel strength and greater interactions between the drug and PVA molecules in case of PVA (1.3×10(5)) compared to PVA (9×10(3)). In order to have an idea about the nature of interactions between the functional moieties of the drug and the polymer unit of PVA, a theoretical study was carried out.

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  • Publisher Full Text
  • Authors

    Bain MK, Bhowmick B, Maity D, Mondal D, Mollick MM, Paul BK, Bhowmik M, Rana D, Chattopadhyay D

    Source

    International journal of biological macromolecules 50:3 2012 Apr 1 pg 565-72

    MeSH

    Drug Carriers
    Gels
    Ketorolac Tromethamine
    Kinetics
    Methylcellulose
    Models, Molecular
    Molecular Conformation
    Molecular Weight
    Ophthalmic Solutions
    Polyvinyl Alcohol
    Rheology
    Temperature
    Viscosity

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22301004