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Quantification of pulsatile cerebrospinal fluid flow within the prepontine cistern.

Abstract

BACKGROUND
Phase-contrast MRI (PC-MRI) has previously been used for the quantification of CSF and blood flow throughout the body. We propose a new method of semi-automated segmentation for the prepontine cistern based on anatomical and pulsatility information.
METHODS
Scans were conducted on 48 patients (69.83 ± 14.28 years) ranging in age from 32 to 88 years along with an additional 11 controls (51.91 ± 21.13 years) ranging in age from 22 to 72 years. The segmentation algorithm developed consists of four stages: anatomical, flow quantification for the aqueduct and prepontine cistern, and blood vessel detection.
RESULTS
Complete results are presented in Table 1, the 37 preoperative patients and controls had a prepontine cistern stroke volume of 464.32 ± 202.30 and 447.38 ± 75.49 respectively.
CONCLUSION
Reliable quantification of volumetric CSF flow in complex cisternal spaces is possible using a methodology combining known anatomical features with the pulsatile nature of CSF flow.

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  • Authors

    Hamilton R, Dye J, Frew A, Baldwin K, Hu X, Bergsneider M

    Institution

    Department of Neurosurgery, University of California, Los Angeles, CA 90095, USA.

    Source

    Acta neurochirurgica. Supplement 114: 2012 pg 191-5

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Algorithms
    Cerebral Aqueduct
    Cerebrospinal Fluid
    Female
    Humans
    Hydrocephalus
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Pons
    Pulsatile Flow
    Reference Values
    Reproducibility of Results
    Stroke Volume
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22327691