Abstract

BACKGROUND
Statins have been shown to reduce mortality and morbidity in ischemic stroke, subarachnoid hemorrhage, and traumatic brain injuries, but their effect on intracerebral hemorrhage (ICH) remains to be determined. This study aimed to investigate the effect of prior statin use on survival following spontaneous primary intracerebral hemorrhage in a multi-ethnic Asian population.
SUBJECTS AND METHODS
A study cohort of patients admitted with spontaneous primary ICH was obtained from our database. There were 1,381 patients who met the inclusion criteria. Multivariate logistic regression was used to identify independent predictors and computed odds ratios for 30-day mortality. Kaplan-Meier and Cox proportional hazard survival analyses were used to examine the effect of prior statin use on survival after ICH.
RESULTS
Multivariate logistic regression controlling for baseline characteristics and in-hospital interventions, did not demonstrate any effect of prior statin use (p = 0.781) on mortality. Survival analyses also failed to demonstrate any differences in survival after ICH with prior statin use. Similarly subgroup analyses showed no difference.
CONCLUSION
No beneficial effect on survival after ICH of prior statin use could be demonstrated in our large multi-ethnic Asian patient cohort.

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Authors

King NK, Tay VK, Allen JC, Ang BT

Institution

Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore.

Source

Acta neurochirurgica. Supplement 114: 2012 pg 343-6

MeSH

Aged
Asian Continental Ancestry Group
Cerebral Hemorrhage
Cohort Studies
Cultural Diversity
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Logistic Models
Male
Middle Aged
Retrospective Studies
Statistics, Nonparametric
Survival Analysis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22327720