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Motor disorders and impaired electrical power of pallidal EEG improved by gallic acid in animal model of Parkinson's disease.

Abstract

The aim of this study was evaluation the effect of Gallic acid on movement disorders and pallidal electrical power in animal model of Parkinson's Disease (PD). PD is clinically characterized by development of motor disturbances, such as bradykinesia, resting tremors, rigidity and a later loss ofpostural reflexes. Oxidative stress is a hallmark factor where the oxidation of dopamine generates Reactive Oxygen Species (ROS) and an unbalanced production ROS induces neuronal damage, therefor leading the neuronal death. Gallic Acid (GA) and its derivatives are present in the plant kingdom and acts as a potent antioxidant. Wistar male rats divided into seven groups randomly with 8 in each. Animals in all groups except control received 8 microg/2 microL 6-hydroxydopamine dissolved in normal saline contains 0.01% ascorbate or vehicle in right Medial Forbrain Bundle (MFB) and a bipolar wire electrode was implanted in the left globus pallidus nucleus of all animals under stereotaxic surgery. Two weeks later PD was approved by contralateral rotation signs induced by apomorphine and then movements and electrical power of pallidal were evaluated. Motor functions and pallidal electrical power were impaired and GA could improve motor dysfunctions and gamma wave power in parkinsonian rats' significantly with higher dose of GA (200 mg kg(-1)). Present result showed that GA may act as a potent antioxidant and free radical scavenger to reverse motor disorders and pallidal gamma wave power after 6-OHDA neurotoxicity in brain.

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  • Authors

    Sameri MJ, Sarkaki A, Farbood Y, Mansouri SM

    Institution

    Department of Physiology, Faculty of Medicine and Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    Source

    Pakistan journal of biological sciences: PJBS 14:24 2011 Dec 15 pg 1109-16

    MeSH

    Adrenergic Agents
    Animals
    Antioxidants
    Disease Models, Animal
    Electroencephalography
    Gallic Acid
    Globus Pallidus
    Humans
    Male
    Medial Forebrain Bundle
    Motor Activity
    Movement Disorders
    Neuropsychological Tests
    Oxidative Stress
    Oxidopamine
    Parkinsonian Disorders
    Random Allocation
    Rats
    Rats, Wistar

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22335050