Abstract

The aim of this study was evaluation the effect of Gallic acid on movement disorders and pallidal electrical power in animal model of Parkinson's Disease (PD). PD is clinically characterized by development of motor disturbances, such as bradykinesia, resting tremors, rigidity and a later loss ofpostural reflexes. Oxidative stress is a hallmark factor where the oxidation of dopamine generates Reactive Oxygen Species (ROS) and an unbalanced production ROS induces neuronal damage, therefor leading the neuronal death. Gallic Acid (GA) and its derivatives are present in the plant kingdom and acts as a potent antioxidant. Wistar male rats divided into seven groups randomly with 8 in each. Animals in all groups except control received 8 microg/2 microL 6-hydroxydopamine dissolved in normal saline contains 0.01% ascorbate or vehicle in right Medial Forbrain Bundle (MFB) and a bipolar wire electrode was implanted in the left globus pallidus nucleus of all animals under stereotaxic surgery. Two weeks later PD was approved by contralateral rotation signs induced by apomorphine and then movements and electrical power of pallidal were evaluated. Motor functions and pallidal electrical power were impaired and GA could improve motor dysfunctions and gamma wave power in parkinsonian rats' significantly with higher dose of GA (200 mg kg(-1)). Present result showed that GA may act as a potent antioxidant and free radical scavenger to reverse motor disorders and pallidal gamma wave power after 6-OHDA neurotoxicity in brain.

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Authors

Sameri MJ, Sarkaki A, Farbood Y, Mansouri SM

Institution

Department of Physiology, Faculty of Medicine and Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Source

Pakistan journal of biological sciences: PJBS 14:24 2011 Dec 15 pg 1109-16

MeSH

Adrenergic Agents
Animals
Antioxidants
Disease Models, Animal
Electroencephalography
Gallic Acid
Globus Pallidus
Humans
Male
Medial Forebrain Bundle
Motor Activity
Movement Disorders
Neuropsychological Tests
Oxidative Stress
Oxidopamine
Parkinsonian Disorders
Random Allocation
Rats
Rats, Wistar

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22335050