Abstract

AIMS
To compare the pharmacodynamics of 0.6 mg kg(-1) rocuronium in young and older patients of both genders during total intravenous anesthesia.
METHODS
Following local ethics committee approval and informed consent, patients scheduled for surgery under total intravenous anesthesia (propofol/sufentanil) were divided into 4 study groups: 37 males aged 20-40, 40 males aged 60-75 yrs, 43 females aged 20-40 and 38 females aged 60-75 yrs. Neuromuscular block following rocuronium (0.6 mg kg(-1)) was monitored: train-of-four [TOF] stimulation of the ulnar nerve at 15-s intervals, EMG of the adductor pollicis muscle. The onset time (from application of rocuronium to maximum depression of T(1)), clinical duration (from application to 25% recovery of T(1)), and time to full spontaneous recovery (from application to TOF-ratio ≥ 0.9) were determined for each patient. The Kruskal-Wallis test was used to compare differences between groups; P<0.05 was considered statistically significant.
RESULTS
The onset time (median [interquartile range]) in the respective groups was 90 [80-110](BCD), 135 [116-165](AC), 75 [60-90](ABD), and 120 [90-146](AC) seconds. The clinical duration was 30 [25-42](BCD), 58 [53-67](AD), 50 [40-65](AD), and 85 [70-90](ABC) min. Interval to full spontaneous recovery was 59 [51-67](BCD), 102 [75-106](A), 76 [66-91](AD), and 128 [94-137](AC) min. ((A)P<0.05 vs. young males, (B)P<0.05 vs. elderly males, (C)P<0.05 vs. young females, (D)P<0.05 vs. elderly females).
CONCLUSION
Females and older patients were more sensitive to rocuronium.

Links

Publisher Full Text

Authors

Adamus M, Hrabalek L, Wanek T, Gabrhelik T, Zapletalova J

Institution

Department of Anesthesiology and Intensive Care Medicine, University Hospital Olomouc, Palacky University Olomouc, Czech Republic. milan.adamus@seznam.cz

Source

Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 155:4 2011 Dec pg 347-53

MeSH

Adult
Aged
Aging
Androstanols
Anesthesia, Intravenous
Female
Humans
Male
Middle Aged
Neuromuscular Blockade
Neuromuscular Nondepolarizing Agents
Sex Characteristics
Young Adult

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22336647