Osteoblastic functions: a lesson from biochemical bone markers.
The present study showed the lowest values of bone markers from osteoblast, NMID osteocalcin, 10.81 +/- 3.9 ng/ ml and PINP 15.88 +/- 7.09 ng/ml at lowest level of osteoclast, betaCTx, 0.066 + 0.22 ng/ml should be the cut value for osteoblastic function. At this level betaCTx, had no correlation with PINP (r = 0.198, p = 0.003) or NMID osteocalcin (r = 0.035, p = 0.606) compared to the normal value of the control group and the correlation (r) between betaCTx and NMID osteocalcin, betaCTx and PINP, which were 0.757 and 0.752 (p = 0.001) respectively and recognized as normal bone turnover with coupling effect. So, bone markers of osteoblast at the lowest value of betaCTx (0.066 ng/ml) with NMID osteocalcin, 10.81 +/- 3.9 ng/ml and PINP 15.887.09 ng/ml may be the cut value of osteoblast reflecting poor functions. The benefit of identifying the cut values of osteoblast will help in making decisions in osteoporotic management.
Department of Orthopaedic Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand. email@example.com
SourceJournal of the Medical Association of Thailand = Chotmaihet thangphaet 94 Suppl 5: 2011 Oct pg S84-6
Pub Type(s)Journal Article