Unbound MEDLINE

Sound-driven synaptic inhibition in primary visual cortex.

Abstract

Multimodal objects and events activate many sensory cortical areas simultaneously. This is possibly reflected in reciprocal modulations of neuronal activity, even at the level of primary cortical areas. However, the synaptic character of these interareal interactions, and their impact on synaptic and behavioral sensory responses are unclear. Here, we found that activation of auditory cortex by a noise burst drove local GABAergic inhibition on supragranular pyramids of the mouse primary visual cortex, via cortico-cortical connections. This inhibition was generated by sound-driven excitation of a limited number of cells in infragranular visual cortical neurons. Consequently, visually driven synaptic and spike responses were reduced upon bimodal stimulation. Also, acoustic stimulation suppressed conditioned behavioral responses to a dim flash, an effect that was prevented by acute blockade of GABAergic transmission in visual cortex. Thus, auditory cortex activation by salient stimuli degrades potentially distracting sensory processing in visual cortex by recruiting local, translaminar, inhibitory circuits.

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  • Authors

    Iurilli G, Ghezzi D, Olcese U, Lassi G, Nazzaro C, Tonini R, Tucci V, Benfenati F, Medini P

    Source

    Neuron 73:4 2012 Feb 23 pg 814-28

    MeSH

    Acoustic Stimulation
    Action Potentials
    Analysis of Variance
    Animals
    Bacterial Proteins
    Conditioning, Classical
    GABA Antagonists
    Luminescent Proteins
    Mice
    Mice, Inbred C57BL
    Mice, Transgenic
    Neural Inhibition
    Neurons
    Phosphinic Acids
    Photic Stimulation
    Picrotoxin
    Propanolamines
    Psychophysics
    Rhodopsin
    Statistics, Nonparametric
    Visual Cortex
    Wakefulness

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22365553