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Intracoronary administration of autologous bone marrow stem cell transplant in myocardial infarction.

Abstract

OBJECTIVE
To elaborate in detail the technique of intracoronary administration of autologous bone marrow stem cell transplantation in patients with acute myocardial infarction.
METHODS
This procedure was carried out during a pilot study which was conducted in the department of interventional cardiology of Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi from June 2004 to November 2006. The inclusion criteria's were recent anterior myocardial infarction with anteroapical hypokinesia and single vessel disease in left anterior descending artery. The informed consent was obtained. After giving local anaesthesia and light sedation, both posterior superior iliac crests were accessed by multiple punctures to get stem cell harvest. The harvest was analyzed to document total and mean mononuclear cell count. An over the wire balloon catheter was parked in mid left anterior descending artery. The stem cells were injected intermittently into the infarcted myocardium during transient balloon inflation over 45-60 minutes. The clinical, left ventricle cineangiographic and nuclear scintigraphic parameters were analyzed and compared at week 0 and 12 to objectively document the effects of stem cell.
RESULTS
The procedure was successfully carried out and well tolerated by all the patients. The minor complications were managed accordingly. Post autologous stem cell therapy, there was amelioration in clinical symptoms, left ventricle ejection fraction and myocardial perfusion.
CONCLUSION
Intracoronary artery infusion of stem cells in acute myocardial infarction is simple, reasonably safe and effective mode of cell delivery in our set up.

Authors

Nuri MM, Hafeez S

Source

JPMA. The Journal of the Pakistan Medical Association 61:1 2011 Jan pg 3-5

MeSH

Angioplasty, Balloon, Coronary
Bone Marrow Transplantation
Cardiac Catheterization
Humans
Male
Myocardial Infarction
Pilot Projects
Stem Cell Transplantation
Transplantation, Autologous
Treatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22368892