Abstract

A novel composite material consisting of a silica aerogel core coated by a poly(ethylene) glycol (PEG) hydrogel was developed. The potential of this novel composite as a drug delivery system was tested with ketoprofen as a model drug due to its solubility in supercritical carbon dioxide. The results indicated that both drug loading capacity and drug release profiles could be tuned by changing hydrophobicity of aerogels, and that drug loading capacity increased with decreased hydrophobicity, while slower release rates were achieved with increased hydrophobicity. Furthermore, higher concentration of PEG diacrylate in the prepolymer solution of the hydrogel coating delayed the release of the drug which can be attributed to the lower permeability at higher PEG diacrylate concentrations. The novel composite developed in this study can be easily implemented to achieve the controlled delivery of various drugs and/or proteins for specific applications.

Links

Publisher Full Text

Authors

Giray S, Bal T, Kartal AM, Kızılel S, Erkey C

Institution

Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey.

Source

Journal of biomedical materials research. Part A 100:5 2012 May pg 1307-15

MeSH

Adsorption
Chemistry, Pharmaceutical
Delayed-Action Preparations
Diffusion
Eosine Yellowish-(YS)
Hydrogel
Hydrophobic and Hydrophilic Interactions
Ketoprofen
Polyethylene Glycols
Porosity
Silicon Dioxide

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22374682