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Biomarkers of oxidative stress in vascular dementia patients.

Abstract

OBJECTIVE
Little is known about the role of oxidative stress in the pathogenesis of vascular dementia (VaD). The aim of this study was to investigate the biomarkers of oxidative stress in urine, as reflected by 8-hydroxydeoxyguanosine (8-OHdG), 8-isoprostaglandin F(2a) (8-isoPGF(2a)) and nitrotyrosine (NT) levels, in a group of well characterized VaD patients and in two control groups of Vascular Not Demented (VaND) patients and health y subjects.
METHODS
Ninety-six subjects from the Tianjin municipality in China were recruited. Forty-six patients were in the VaD group, 24 patients with VaND and 26 persons with no signs of cognitive disorder were employed as control groups. Urinary 8-OHdG and 8-isoPGF(2a) was performed using enzyme-linked immunosorbent assay (ELISA), and urinary NT levels were measured by chemiluminescence detection.
RESULTS
Significantly higher urinary 8-OHdG levels were detected in VaD patients compared to VaND patients and healthy control subjects. In contrast, urinary 8-isoPGF(2a) levels were significantly lower in VaD patients compared with two control groups. For NT levels, no statistically significant differences were observed among the three groups.
CONCLUSION
Increased urinary 8-OHdG level was a potential marker of oxidative stress in VaD patients. Furthermore, it is also important to take into account potential confounders in order to improve the identification of changes in the status of oxidative stress as related to VaD.

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  • Publisher Full Text
  • Authors

    Shi GX, Liu CZ, Wang LP, Guan LP, Li SQ

    Institution

    Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing, China.

    Source

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 39:1 2012 Jan pg 65-8

    MeSH

    Aged
    Biological Markers
    Dementia, Vascular
    Deoxyguanosine
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Isoprostanes
    Male
    Middle Aged
    Oxidative Stress
    Tyrosine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22384487