Unbound MEDLINE

Disseminated Sporothrix brasiliensis infection with endocardial and ocular involvement in an HIV-infected patient.

Abstract

Disseminated sporotrichosis occurs in individuals with impaired cellular immunity, such as in cases of neoplasia, transplantation, diabetes, and especially, acquired immunodeficiency syndrome. This report presents a 32-year-old Brazilian human immunodeficiency virus (HIV)-infected patient who developed a protracted condition of disseminated sporotrichosis with endocarditis, bilateral endophthalmitis, and lymphatic involvement. He needed cardiac surgery to replace the mitral valve. Sporothrix brasiliensis isolates were recovered from cultures of subcutaneous nodules and mitral valve fragments. Species identification was based on classical and molecular methods. The patient received amphotericin B for 52 days and subsequently, oral itraconazole. He remains asymptomatic, and he is on maintenance therapy with itraconazole. Despite his positive clinical outcome, he developed bilateral blindness. To our knowledge, this case is the first report of endocarditis and endophthalmitis caused by S. brasiliensis.

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  • Authors

    Silva-Vergara ML, de Camargo ZP, Silva PF, Abdalla MR, Sgarbieri RN, Rodrigues AM, dos Santos KC, Barata CH, Ferreira-Paim K

    Source

    The American journal of tropical medicine and hygiene 86:3 2012 Mar pg 477-80

    MeSH

    AIDS-Related Opportunistic Infections
    Adult
    Amphotericin B
    Antifungal Agents
    Antiretroviral Therapy, Highly Active
    Brazil
    Endophthalmitis
    Eye
    HIV
    Hospitalization
    Humans
    Itraconazole
    Male
    Sporothrix
    Sporotrichosis
    Treatment Outcome
    Vision, Ocular

    Pub Type(s)

    Case Reports
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22403321