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Dengue hemorrhagic fever in Trinidad and Tobago: a case for a conservative approach to platelet transfusion.

Abstract

Dengue fever is endemic to Trinidad and Tobago. A retrospective analysis of all adult admissions at a tertiary hospital in Trinidad treated for dengue during January 1-December 31, 2008 was performed. A total of 186 patients were treated during this period: 98.9% (184) of the patients were thrombocytopenic; 45.2% were severely thrombocytopenic; 13 patients showed development of minor hemorrhage and only one case of major hemorrhage; platelet transfusion was given for 7% (13) of the cases; and 6 cases for which platelet transfusion was given did not show evidence of plasma leakage (12 of these cases did not show evidence of hemorrhage). There was a strong association between the lowest platelet value and hemoconcentration (χ(2) = 13.16, P < 0.025). No association was found between giving a platelet transfusion and hemoconcentration or hemorrhage. Thrombocytopenia seen in dengue resolves spontaneously and independent of any transfusion used.

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  • Authors

    Sharma A, Charles K, Chadee D, Teelucksingh S

    Institution

    Department of Clinical Medical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago. anu.sharma@gmail.com

    Source

    The American journal of tropical medicine and hygiene 86:3 2012 Mar pg 531-5

    MeSH

    Adolescent
    Adult
    Dengue Hemorrhagic Fever
    Female
    Hemorrhage
    Humans
    Male
    Middle Aged
    Platelet Transfusion
    Retrospective Studies
    Thrombocytopenia
    Trinidad and Tobago
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22403331