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Dengue hemorrhagic fever in Trinidad and Tobago: a case for a conservative approach to platelet transfusion.

Abstract

Dengue fever is endemic to Trinidad and Tobago. A retrospective analysis of all adult admissions at a tertiary hospital in Trinidad treated for dengue during January 1-December 31, 2008 was performed. A total of 186 patients were treated during this period: 98.9% (184) of the patients were thrombocytopenic; 45.2% were severely thrombocytopenic; 13 patients showed development of minor hemorrhage and only one case of major hemorrhage; platelet transfusion was given for 7% (13) of the cases; and 6 cases for which platelet transfusion was given did not show evidence of plasma leakage (12 of these cases did not show evidence of hemorrhage). There was a strong association between the lowest platelet value and hemoconcentration (χ(2) = 13.16, P < 0.025). No association was found between giving a platelet transfusion and hemoconcentration or hemorrhage. Thrombocytopenia seen in dengue resolves spontaneously and independent of any transfusion used.

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  • Authors

    Sharma A, Charles K, Chadee D, Teelucksingh S

    Source

    The American journal of tropical medicine and hygiene 86:3 2012 Mar pg 531-5

    MeSH

    Adolescent
    Adult
    Female
    Hemorrhage
    Humans
    Male
    Middle Aged
    Platelet Transfusion
    Retrospective Studies
    Severe Dengue
    Thrombocytopenia
    Trinidad and Tobago
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22403331