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Hydroxyapatite-alginate nanocomposite as drug delivery matrix for sustained release of ciprofloxacin.

Abstract

Hydroxyapatite is a bioceramic which has a wide range of medical application for bone diseases. To enhance its usage, we have prepared ciprofloxacin loaded nano hydroxyapatite (HA) composite with a natural polymer, alginate, using wet chemical method at low temperature. The prepared composites were analyzed by various physicochemical methods. The results show that the nano HA crystallites are well intact with the alginate macromolecules. For the composite system FT-IR and micro Raman results are reported in this paper. Studies on the drug loading and drug release have been done. The drug is pre-adsorbed onto the ceramic particle before the formation of composite. The thermal behavior of composite has been studied using thermo gravimetric analysis (TGA). This work, reports that the nanocomposite prepared under optimum condition could prolong the release of ciprofloxacin compared with the ciprofloxacin loaded hydroxyapatite.

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  • Publisher Full Text
  • Authors

    Venkatasubbu GD, Ramasamy S, Ramakrishnan V, Kumar J

    Institution

    Crystal Growth Centre, Anna University, Chennai-600025, Tamilnadu, India.

    Source

    Journal of biomedical nanotechnology 7:6 2011 Dec pg 759-67

    MeSH

    Alginates
    Anti-Infective Agents
    Ciprofloxacin
    Delayed-Action Preparations
    Drug Carriers
    Durapatite
    Glucuronic Acid
    Hexuronic Acids
    Nanocomposites

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22416574