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Low pathogenic H7 subtype avian influenza viruses isolated from domestic ducks in South Korea and the close association with isolates of wild birds.

Abstract

We characterized low pathogenic avian influenza (LPAI) viruses of the H7 subtype that were isolated from domestic ducks and wild birds in South Korea from 2008 to 2011. A total of 20 H7 viruses were collected from live-bird markets (LBMs), duck farms and wild-bird habitats using avian influenza (AI) surveillance and epidemiological approaches. A phylogenetic analysis of the H7 viruses that were isolated from domestic ducks and wild birds demonstrated that they were separated into 12 genotypes (A-D and Wb-1-8, respectively), indicating genetic diversity. These H7 viruses were related to the recently isolated Eurasian LPAI H7 viruses and various influenza viruses that are circulating in Asia, including southern China and South Korea. The same genotype was not found between domestic poultry and wild-bird isolates; however, most of the H7 viruses in poultry (genotypes B and C) were closely related to the H7 virus isolated from a wild bird (genotype Wb-3). Animal-challenge studies revealed that certain H7 AI viruses replicated well only in chickens or ducks depending on the genotype, indicating that the pathogenicity of H7 viruses has the potential to be altered due to multiple reassortments, and these viruses can potentially expand their host range. Our results are evidence of abundant and frequent reassortment between H7 viruses in poultry and wild birds and emphasize the continuing need to monitor the evolutionary genetics of the influenza virus in poultry and wild birds.

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  • Publisher Full Text

    • Authors

    Kim HR, Park CK, Lee YJ, Oem JK, Kang HM, Choi JG, Lee OS, Bae YC

    Institution

    Animal Disease Diagnosis Division, Animal, Plant and Fisheries Quarantine and Inspection Agency, 175 Anyangro, Manangu, Anyangsi, Gyeonggido 430-757, Republic of Korea.

    Source

    The Journal of general virology 93:Pt 6 2012 Jun pg 1278-87

    MeSH

    Animals
    Animals, Wild
    Anseriformes
    Ducks
    Genotype
    Influenza A virus
    Influenza in Birds
    Molecular Sequence Data
    Phylogeny
    Poultry Diseases
    Republic of Korea
    Virulence

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22422062