Unbound MEDLINE

Intermuscular relationship of human muscle fiber type proportions: slow leg muscles predict slow neck muscles.

Abstract

INTRODUCTION
Our aim in this study was to examine whether the muscle fiber type proportions in different muscles from the same individual are interrelated.
METHODS
Samples were excised from five skeletal muscles in each of 12 human autopsy cases, and the fiber type proportions were determined by immunohistochemistry. We further examined the intermuscular relationship in fiber type proportion by reanalyzing three previously published data sets involving other muscles.
RESULTS
Subjects demonstrated a predominantly high or low proportion of type 1 fibers in all examined muscles, and the overall difference between individuals was statistically significant (P < 0.001). Accordingly, the type 1 fiber proportions in most muscles were positively correlated (median r = 0.42, range -0.03-0.80). Similar results were also obtained from the three reanalyzed data sets.
CONCLUSIONS
We suggest the existence of an across-muscle phenotype with respect to fiber type proportions; some individuals display generally faster muscles and some individuals slower muscles when compared with others.

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  • Publisher Full Text
  • Authors

    Vikne H, Gundersen K, Liestøl K, Maelen J, Vøllestad N

    Institution

    Department of Health Sciences, University of Oslo, P.O. Box 1089 Blindern, N-0317 Oslo, Norway. harald.vikne@medisin.uio.no.

    Source

    Muscle & nerve 45:4 2012 Apr pg 527-35

    MeSH

    Adult
    Aged
    Anatomy, Cross-Sectional
    Autopsy
    Cell Count
    Cell Size
    Coloring Agents
    Female
    Fluorescent Antibody Technique
    Humans
    Leg
    Male
    Middle Aged
    Muscle Contraction
    Muscle Fibers, Fast-Twitch
    Muscle Fibers, Slow-Twitch
    Muscle, Skeletal
    Neck Muscles

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22431086