Abstract

INTRODUCTION
This study was designed to assess the effect of extracorporeal shock-wave lithotripsy (ESWL) exposure of the parotid gland on oxidative stress and some trace element levels in the facial nerves of rats.
METHODS
Twelve male Wistar albino rats were divided into two groups, each consisting of 6 animals. The rats in the first group served as controls. The left parotid glands of animals in the second group were treated with 1000 18-kV shock waves while anesthetized with ketamine. The animals in both groups were euthanized 72 h after the ESWL treatment, and the right facial nerve was harvested for determination of oxidant/antioxidant status and trace element levels.
RESULTS
Lipid peroxidation product malondialdehyde (MDA) and antioxidant glutathione (GSH) levels increased, and the activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), decreased in the facial nerves of ESWL-treated rats. The levels of iron, lead, manganese, and cobalt increased, and magnesium, cadmium, and copper levels decreased.
CONCLUSIONS
ESWL treatment of the parotid gland may increase lipid peroxidation and decrease antioxidant enzyme activity in adjacent tissues such as the facial nerve. It also causes a decrease or increase in many mineral levels of the facial nerve, which is an undesirable condition for normal physiological function.

Links

Publisher Full Text

Authors

Kavak S, Garca MF, Gecit I, Meral I, Cengiz N, Demir H

Institution

Department of Biophysics, Faculty of Medicine, Yüzüncü Yıl University, 65100 Van, Turkey. skavak@yyu.edu.tr

Source

Muscle & nerve 45:4 2012 Apr pg 562-6

MeSH

Animals
Catalase
Facial Nerve
Glutathione Peroxidase
Lipid Peroxidation
Lithotripsy
Male
Malondialdehyde
Metals, Heavy
Oxidative Stress
Parotid Gland
Rats
Rats, Wistar
Salivary Gland Calculi
Superoxide Dismutase
Trace Elements

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22431090