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Effects of extracorporeal shock-wave lithotripsy directed at the parotid gland on oxidative stress parameters and some trace element levels in facial nerve of rats.

Abstract

INTRODUCTION
This study was designed to assess the effect of extracorporeal shock-wave lithotripsy (ESWL) exposure of the parotid gland on oxidative stress and some trace element levels in the facial nerves of rats.
METHODS
Twelve male Wistar albino rats were divided into two groups, each consisting of 6 animals. The rats in the first group served as controls. The left parotid glands of animals in the second group were treated with 1000 18-kV shock waves while anesthetized with ketamine. The animals in both groups were euthanized 72 h after the ESWL treatment, and the right facial nerve was harvested for determination of oxidant/antioxidant status and trace element levels.
RESULTS
Lipid peroxidation product malondialdehyde (MDA) and antioxidant glutathione (GSH) levels increased, and the activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), decreased in the facial nerves of ESWL-treated rats. The levels of iron, lead, manganese, and cobalt increased, and magnesium, cadmium, and copper levels decreased.
CONCLUSIONS
ESWL treatment of the parotid gland may increase lipid peroxidation and decrease antioxidant enzyme activity in adjacent tissues such as the facial nerve. It also causes a decrease or increase in many mineral levels of the facial nerve, which is an undesirable condition for normal physiological function.

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  • Publisher Full Text
  • Authors

    Kavak S, Garca MF, Gecit I, Meral I, Cengiz N, Demir H

    Source

    Muscle & nerve 45:4 2012 Apr pg 562-6

    MeSH

    Animals
    Catalase
    Facial Nerve
    Glutathione Peroxidase
    Lipid Peroxidation
    Lithotripsy
    Male
    Malondialdehyde
    Metals, Heavy
    Oxidative Stress
    Parotid Gland
    Rats
    Rats, Wistar
    Salivary Gland Calculi
    Superoxide Dismutase
    Trace Elements

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22431090