Abstract

INTRODUCTION
Expression of c-fos initiated by muscle proprioceptive signaling was studied in rats after inhibition of neuronal nitric oxide synthase (nNOS) with administration of 7-nitroindazole (7-NI).
METHODS
Fos-immunoreactive (Fos-ir) neurons were visualized immunohistochemically in the lumbar cord after vibration of the Achilles tendon and/or 7-NI systemic injections.
RESULTS
The total number of Fos-ir interneurons and motoneurons (per slice) was significantly greater in the 7-NI-pretreated and tendon-vibrated (7-NI + Tv) group than in the isolated tendon vibration group (Tv group). The greatest increases in the number of Fos-ir neurons were found in the L4 (+100%) and L5 (+105%) segments (P < 0.05).
CONCLUSIONS
Suppression of NO release after introduction of 7-NI was associated with potentiation of Fos immunoreactivity induced by muscle proprioceptive signaling within distinctive regions of the spinal cord.

Links

Publisher Full Text

Authors

Pilyavskii AI, Maisky VA, Maznychenko AV, Kostyukov AI

Institution

Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Bogomoletz Str. 4, Kiev 01024, Ukraine. pil@biph.kiev.ua

Source

Muscle & nerve 45:4 2012 Apr pg 597-602

MeSH

Achilles Tendon
Animals
Cell Count
Enzyme Inhibitors
Gene Expression
Genes, fos
Immunohistochemistry
Indazoles
Injections, Intraperitoneal
Interneurons
Male
Motor Neurons
Muscle, Skeletal
Neurons, Afferent
Nitric Oxide Synthase Type I
Proprioception
Rats
Rats, Wistar
Spinal Cord
Tendons
Vibration

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22431094