Abstract

OBJECTIVE
To evaluate the insulin requirements in women with type 1 diabetes during twin pregnancy compared with singleton pregnancy.
RESEARCH DESIGN AND METHODS
At 8, 14, 21, 27, and 33 gestational weeks, insulin requirements and HbA(1c) were compared between 15 twin pregnant women from 2000 to 2011 and 108 singleton pregnant women from 2004 to 2006.
RESULTS
In twin pregnancies, the weekly increase in daily insulin dose between 14 and 27 weeks was higher than in singleton pregnancies (median 3.0 international units [IU] [range 0.9-4.9] versus 1.5 IU [-1.5 to 5.9]; P = 0.008) and remained stable from 27 to 33 weeks. The increment in total insulin requirement from before pregnancy until 33 weeks tended to be higher in twin pregnancies (103% [36-257%] versus 71% [-20 to 276%]; P = 0.07). Throughout pregnancy, HbA(1c) was similar in twin and singleton pregnancies.
CONCLUSIONS
In twin pregnancies, the weekly increase in insulin dose between 14 and 27 weeks was doubled compared with singleton pregnancies.

Links

Publisher Full Text

Authors

Callesen NF, Ringholm L, Stage E, Damm P, Mathiesen ER

Institution

Center for PregnantWomen with Diabetes, Rigshospitalet, Copenhagen, Denmark. nicolinecallesen@gmail.com

Source

Diabetes care 35:6 2012 Jun pg 1246-8

MeSH

Adult
Blood Glucose
Blood Glucose Self-Monitoring
Blood Pressure
Diabetes Mellitus, Type 1
Diabetic Retinopathy
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Hemoglobin A, Glycosylated
Humans
Hypoglycemic Agents
Insulin
Pregnancy
Pregnancy in Diabetics
Pregnancy, Twin
Young Adult

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22432115