Unbound MEDLINE

Insulin requirements in type 1 diabetic pregnancy: do twin pregnant women require twice as much insulin as singleton pregnant women?

Abstract

OBJECTIVE
To evaluate the insulin requirements in women with type 1 diabetes during twin pregnancy compared with singleton pregnancy.
RESEARCH DESIGN AND METHODS
At 8, 14, 21, 27, and 33 gestational weeks, insulin requirements and HbA(1c) were compared between 15 twin pregnant women from 2000 to 2011 and 108 singleton pregnant women from 2004 to 2006.
RESULTS
In twin pregnancies, the weekly increase in daily insulin dose between 14 and 27 weeks was higher than in singleton pregnancies (median 3.0 international units [IU] [range 0.9-4.9] versus 1.5 IU [-1.5 to 5.9]; P = 0.008) and remained stable from 27 to 33 weeks. The increment in total insulin requirement from before pregnancy until 33 weeks tended to be higher in twin pregnancies (103% [36-257%] versus 71% [-20 to 276%]; P = 0.07). Throughout pregnancy, HbA(1c) was similar in twin and singleton pregnancies.
CONCLUSIONS
In twin pregnancies, the weekly increase in insulin dose between 14 and 27 weeks was doubled compared with singleton pregnancies.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors

    Callesen NF, Ringholm L, Stage E, Damm P, Mathiesen ER

    Source

    Diabetes care 35:6 2012 Jun pg 1246-8

    MeSH

    Adult
    Blood Glucose
    Blood Glucose Self-Monitoring
    Blood Pressure
    Diabetes Mellitus, Type 1
    Diabetic Retinopathy
    Dose-Response Relationship, Drug
    Drug Administration Schedule
    Female
    Hemoglobin A, Glycosylated
    Humans
    Hypoglycemic Agents
    Insulin
    Pregnancy
    Pregnancy in Diabetics
    Pregnancy, Twin
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    22432115