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Predictors of mortality over 8 years in type 2 diabetic patients: Translating Research Into Action for Diabetes (TRIAD).

Abstract

OBJECTIVE
To examine demographic, socioeconomic, and biological risk factors for all-cause, cardiovascular, and noncardiovascular mortality in patients with type 2 diabetes over 8 years and to construct mortality prediction equations.
RESEARCH DESIGN AND METHODS
Beginning in 2000, survey and medical record information was obtained from 8,334 participants in Translating Research Into Action for Diabetes (TRIAD), a multicenter prospective observational study of diabetes care in managed care. The National Death Index was searched annually to obtain data on deaths over an 8-year follow-up period (2000-2007). Predictors examined included age, sex, race, education, income, smoking, age at diagnosis of diabetes, duration and treatment of diabetes, BMI, complications, comorbidities, and medication use.
RESULTS
There were 1,616 (19%) deaths over the 8-year period. In the most parsimonious equation, the predictors of all-cause mortality included older age, male sex, white race, lower income, smoking, insulin treatment, nephropathy, history of dyslipidemia, higher LDL cholesterol, angina/myocardial infarction/other coronary disease/coronary angioplasty/bypass, congestive heart failure, aspirin, β-blocker, and diuretic use, and higher Charlson Index.
CONCLUSIONS
Risk of death can be predicted in people with type 2 diabetes using simple demographic, socioeconomic, and biological risk factors with fair reliability. Such prediction equations are essential for computer simulation models of diabetes progression and may, with further validation, be useful for patient management.

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  • Authors

    McEwen LN, Karter AJ, Waitzfelder BE, Crosson JC, Marrero DG, Mangione CM, Herman WH

    Institution

    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. lmattei@med.umich.edu

    Source

    Diabetes care 35:6 2012 Jun pg 1301-9

    MeSH

    Body Mass Index
    Cardiovascular Diseases
    Comorbidity
    Diabetes Mellitus, Type 2
    Diabetic Angiopathies
    Female
    Follow-Up Studies
    Hemoglobin A, Glycosylated
    Humans
    Male
    Predictive Value of Tests
    Prospective Studies
    Reproducibility of Results
    Risk Assessment
    Risk Factors
    Translational Medical Research
    United States

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    22432119