Unbound MEDLINE

The collapsin response mediator protein 5 onconeural protein is expressed in Schwann cells under axonal signals and regulates axon-Schwann cell interactions.

Abstract

Collapsin response mediator protein 5 (CRMP5) is one of the rare peripheral nerve antigens that is a target of autoantibodies in a paraneoplastic peripheral neuropathy. The pattern of axonal and myelin alterations suggests that CRMP5 is involved in axon-Schwann cell interaction. We examined CRMP5 expression and function in primary cultures of Schwann cells and neurons and at various developmental and regenerating stages of rat sciatic nerve and in CRMP5-deficient mice in vivo. Collapsin response mediator protein 5 was strongly expressed during postnatal development and regeneration and decreased with myelination. It was mainly expressed by immature Schwann cells and persisted in Remak cells in the adult; however, a subpopulation of Schwann cells that were induced to myelinate also expressed CRMP5. We identified 2 axonal molecular cues regulating CRMP5 expression: human neuregulin type 1, which induces CRMP5 expression in immature and premyelinating Schwann cells, and cyclic adenosine monophosphate, which inhibits CRMP5 expression when Schwann cells begin myelination. Collapsin response mediator protein 5-deficient mice showed abnormal Schwann process extension resulting in abnormal cell-axon segregation, indicating that CRMP5 is involved in the morphologic adaptation of Schwann cells to surround axons. These results demonstrate the importance of CRMP5 in axon-Schwann cell cooperation during development and regeneration.

Links

  • Publisher Full Text
  • Authors

    Camdessanché JP, Ferraud K, Boutahar N, Lassablière F, Mutter M, Touret M, Kolattukudy P, Honnorat J, Antoine JC

    Source

    Journal of neuropathology and experimental neurology 71:4 2012 Apr pg 298-311

    MeSH

    Amidohydrolases
    Animals
    Animals, Newborn
    Axons
    Cell Communication
    Cells, Cultured
    Coculture Techniques
    Gene Expression Regulation
    Humans
    Mice
    Mice, Knockout
    Nerve Tissue Proteins
    Rats
    Schwann Cells
    Signal Transduction

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22437341