Abstract

We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.

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Authors

Surina NM, Kalinina TS, Volkova AV, Malikova LA, Poletaeva II, Rayevsky KS, Fedotova IB

Institution

Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. opera_ghost@inbox.ru

Source

Bulletin of experimental biology and medicine 151:1 2011 May pg 47-50

MeSH

Animals
Anti-Anxiety Agents
Anticonvulsants
Anxiety
Benzimidazoles
Epilepsy, Reflex
Genetic Predisposition to Disease
Injections, Intraperitoneal
Male
Maze Learning
Morpholines
Motor Activity
Piracetam
Rats
Rats, Inbred Strains
Rats, Long-Evans
Rats, Wistar
Severity of Illness Index

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22442800