Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.
We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.
Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. email@example.com
SourceBulletin of experimental biology and medicine 151:1 2011 May pg 47-50
Genetic Predisposition to Disease
Rats, Inbred Strains
Severity of Illness Index
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't