Abstract

OBJECTIVE
To establish fetal thyroid nomograms based on gestational age and biparietal diameter and to compare obtained results with previously published data.
STUDY DESIGN
A cross-sectional study of 241 healthy pregnant women at 14-38 week of gestation was undertaken. Exclusion criteria were: known maternal thyroid or systemic disease, unknown date of last menstrual period, multiple pregnancy and fetal malformations. Fetal thyroid diameter (FTD), circumference (FTC) and area (FTA) were measured by two-dimensional ultrasonography and plotted against gestational age (GA) and biparietal diameter (BPD).
RESULTS
FTD, FTC and FTA increased logarithmically to GA and BPD. Fetal thyroid measurements as a function of GA were expressed by logarithmic formulas: ln(FTD)=3.6025-23.0315/GA, ln(FTC)=4.6227-22.8003/GA, ln(FTA)=6.6303-45.0831/GA. The following logarithmic formulas were obtained for fetal thyroid measurements according to BPD: ln(FTD)=3.4068-45.4271/BPD, ln(FTC)=4.4271-44.8359/BPD, ln(FTA)=6.2390-88.4408/BPD. There were highly significant correlations between thyroid measurements and GA or BPD: r=0.87-0.90, p<0.00001.
CONCLUSIONS
We have established age-dependent and age-independent nomograms of fetal thyroid. These nomograms will enable prenatal diagnosis in fetuses at risk of thyroid disorders.

Links

Publisher Full Text

Authors

Gietka-Czernel M, Dębska M, Kretowicz P, Dębski R, Zgliczyński W

Institution

Department of Endocrinology, Medical Center of Postgraduate Education, Warsaw, Poland. malgietka@vp.pl

Source

European journal of obstetrics, gynecology, and reproductive biology 162:2 2012 Jun pg 131-8

MeSH

Cross-Sectional Studies
Female
Fetal Diseases
Gestational Age
Humans
Iodine
Nomograms
Poland
Pregnancy
Reference Values
Thyroid Diseases
Thyroid Gland
Ultrasonography, Prenatal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22445205