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Computed tomography perfusion analysis of pancreatic carcinoma.

Abstract

OBJECTIVE
The purpose of this study was to evaluate CT perfusion of pancreatic carcinomas using the Patlak model for assessing perfusion, permeability, and blood volume.
METHODS
A total of 25 patients with pancreatic carcinoma were examined prospectively with a 64-slice computed tomography (CT) using a dynamic sequence after intravenous injection of 80-mL contrast material (370 mg/mL; flow rate, 5 mL/s). Eighty-kilovolt (peak) perfusion acquisitions were evaluated for estimating perfusion parameters for carcinoma and healthy tissue using a 2-compartment model (Patlak model).
RESULTS
Twenty patients had hypodense tumors; in 5 patients, the tumor could not be delineated in contrast-enhanced CT. All carcinomas could be identified clearly in the color-coded perfusion maps. Perfusion, permeability, and blood volume values were significant lower in pancreatic carcinomas compared to healthy pancreatic tissue (0.27 ± 0.20 vs 0.89 ± 0.19 min, P < 0.0001; 0.43 ± 0.20 vs 0.75 ± 0.16 × 0.5 min, P < 0.0001; and 38.9 ± 20.7 vs 117.8 ± 46.9 mL/100 mL, P < 0.0001).
CONCLUSION
Computed tomographic perfusion of the pancreas using a 2-compartment perfusion model is feasible. Color-coded perfusion maps could be a helpful tool to delineate pancreatic carcinomas even if they are not visible in contrast-enhanced CT.

Links

  • Publisher Full Text
  • Authors

    Klauss M, Stiller W, Fritz F, Kieser M, Werner J, Kauczor HU, Grenacher L

    Source

    Journal of computer assisted tomography 36:2 pg 237-42

    MeSH

    Adult
    Aged
    Contrast Media
    Female
    Humans
    Iohexol
    Male
    Middle Aged
    Pancreatectomy
    Pancreatic Neoplasms
    Prospective Studies
    Radiographic Image Interpretation, Computer-Assisted
    Tomography, X-Ray Computed

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22446366