Abstract

Phosphate in manure of monogastric animals pollutes the environment if improperly applied to soil. Strategies that reduce phosphate inputs into animal production systems reduce environmental pollution. Using a novel vaccine to fibroblast growth factor-23 (FGF-23), we induced neutralizing antibodies that reduced the phosphate requirement of growing chickens. Breeding hens were injected with a FGF-23 peptide (AFLPGMNP) conjugate. Antibody was passively transferred from hen to chick and chick response to deficient dietary phosphate intake was determined. Chicks without passive anti-FGF-23 antibody had a 43% and 21% reduction in blood phosphate and bone ash, respectively, when fed a phosphate deficient diet and compared to chicks fed a phosphate replete diet (P<0.05). Chicks with circulating anti-FGF-23 antibodies fed the phosphate deficient diet had plasma phosphate and bone ash that did not differ from chicks fed the phosphate replete diet (P>0.05). Neutralization of FGF-23 offers a new approach to reduce phosphate requirements of farmed animals and may provide a new means to reduce phosphate pollution related to animal farming.

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Publisher Full Text

Authors

Bobeck EA, Burgess KS, Jarmes TR, Piccione ML, Cook ME

Institution

Animal Sciences Department, 1675 Observatory Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.

Source

Biochemical and biophysical research communications 420:3 2012 Apr 13 pg 666-70

MeSH

Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Antibodies
Chickens
Environmental Pollutants
Fibroblast Growth Factors
Humans
Manure
Nutritional Requirements
Phosphates
Protein Structure, Secondary

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22450330