Unbound MEDLINE

Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks.

Abstract

Phosphate in manure of monogastric animals pollutes the environment if improperly applied to soil. Strategies that reduce phosphate inputs into animal production systems reduce environmental pollution. Using a novel vaccine to fibroblast growth factor-23 (FGF-23), we induced neutralizing antibodies that reduced the phosphate requirement of growing chickens. Breeding hens were injected with a FGF-23 peptide (AFLPGMNP) conjugate. Antibody was passively transferred from hen to chick and chick response to deficient dietary phosphate intake was determined. Chicks without passive anti-FGF-23 antibody had a 43% and 21% reduction in blood phosphate and bone ash, respectively, when fed a phosphate deficient diet and compared to chicks fed a phosphate replete diet (P<0.05). Chicks with circulating anti-FGF-23 antibodies fed the phosphate deficient diet had plasma phosphate and bone ash that did not differ from chicks fed the phosphate replete diet (P>0.05). Neutralization of FGF-23 offers a new approach to reduce phosphate requirements of farmed animals and may provide a new means to reduce phosphate pollution related to animal farming.

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  • Publisher Full Text
  • Authors

    Bobeck EA, Burgess KS, Jarmes TR, Piccione ML, Cook ME

    Institution

    Animal Sciences Department, 1675 Observatory Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.

    Source

    Biochemical and biophysical research communications 420:3 2012 Apr 13 pg 666-70

    MeSH

    Animal Feed
    Animal Nutritional Physiological Phenomena
    Animals
    Antibodies
    Chickens
    Environmental Pollutants
    Fibroblast Growth Factors
    Humans
    Manure
    Nutritional Requirements
    Phosphates
    Protein Structure, Secondary

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22450330