Unbound MEDLINE

Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes.

Abstract

Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.

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  • Publisher Full Text

    • Authors

    Schmidt SF, Jørgensen M, Sandelin A, Mandrup S

    Institution

    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

    Source

    Transcription 3:1 pg 19-24

    MeSH

    3T3-L1 Cells
    Adipocytes
    Animals
    Binding Sites
    CCAAT-Enhancer-Binding Proteins
    Chromatin Immunoprecipitation
    Histones
    Humans
    Mice
    PPAR gamma
    Protein Binding

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22456316