Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes.
Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
SourceTranscription 3:1 pg 19-24
Pub Type(s)Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't