Unbound MEDLINE

The effect of antituberculosis treatment on interferon-gamma release assay results.

Abstract

BACKGROUND AND AIM
Monitoring the efficacy of antituberculosis therapy is crucial. The aim of this work is to investigate the effect of tuberculosis treatment on interferon-gamma response using Quanti-FERON-TB Gold in tube (QFT-GIT).
METHODS
A total of 216 new pulmonary tuberculosis (TB) cases were tested with QFT-GIT at the start of the treatment and, randomly, once or twice between 90 and 180 days afterwards. Data was analysed using the random effect regression model analysis.
RESULTS
63.4% of patients were positive at the QFT-GIT (> .35 UI cut-off). TB cases showed a significant log-linear increase in interferon-gamma (IFN-gamma) concentration, over time of treatment: IFN-gamma concentration increased by 78% after 6 months of treatment in acid-fast bacilli positive (A) and culture negative cases in culture confirmed cases the increase was 43% if A+ and 20% in A-.
CONCLUSIONS
Effective therapy seems to restore cellular responses to Mycobacterium tuberculosis antigens. The potential use of interferon gamma release assay (IGRA) in monitoring response to TB treatment is hampered by the presence of active mycobacterial replication at baseline and needs further evaluation.

Authors

Bugiani M, Bonora S, Carosso A, Piccioni P, Cavallero M, Mondo A, Ghisetti V

Source

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 75:4 2011 Dec pg 215-9

MeSH

Adult
Antigens, Bacterial
Antitubercular Agents
Bacteriological Techniques
Female
Humans
Immunity, Cellular
Immunoassay
Interferon-gamma
Linear Models
Male
Monitoring, Physiologic
Mycobacterium tuberculosis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22462309