Unbound MEDLINE

Distinct impacts of syndesmophyte formation on male and female patients with ankylosing spondylitis.

Abstract

AIM
Ankylosing spondylitis (AS), a chronic inflammatory autoimmune disease, mainly affects the axial skeleton, leading to sacroiliitis and rigidity of the spine. Both spinal rigidity and syndesmophyte development can affect bone formation and resorption. In addition, inflammatory cytokines and cell adhesion molecules are correlated with bone metabolism. The aim of this study was to investigate the effects of gender difference and syndesmophyte formation on cytokines, adhesion molecules and bone metabolism markers in AS patients.
METHOD
Eighty-seven AS patients (68 males, 19 females) were enrolled in this study. Electrochemiluminescence immunoassay and enzyme-linked immunosorbent assay were performed to measure studied parameters.
RESULTS
Regarding gender, the serum levels of C-terminal crosslinking telopeptide of type I collagen (CTX), vascular endothelial growth factor, soluble vascular cell adhesion molecule-1, tumor necrosis factor alpha and interleukin (IL)-18 in male patients were all significantly higher than those in female patients. The serum levels of osteocalcin and type I procollagen N-terminal propeptide showed downward trends, whereas CTX and parathyroid hormone concentrations were remarkably lower and IL-18 levels were significantly higher in male AS patients with syndesmophytes compared to those without syndesmophytes. In female patients, CTX and IL-6 levels in those with syndesmophytes were significantly higher than in those without syndesmophytes. Cytokines, adhesion molecules and bone metabolism markers were all positively related with syndesmophyte formation and gender differences.
CONCLUSION
AS patients with syndesmophytes experienced imbalance of bone metabolism due to inflammatory cytokine release. Male AS patients had high levels of bone resorption markers, cytokines and adhesion molecules, reflecting a disorder of bone metabolism.

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  • Publisher Full Text
  • Authors

    Huang WN, Tso TK, Kuo YC, Tsay GJ

    Source

    International journal of rheumatic diseases 15:2 2012 Apr pg 163-8

    MeSH

    Adult
    Biological Markers
    Bone Remodeling
    Bone and Bones
    Cell Adhesion Molecules
    Collagen Type I
    Cytokines
    Female
    Humans
    Inflammation
    Male
    Osteocalcin
    Osteophyte
    Parathyroid Hormone
    Peptide Fragments
    Peptides
    Procollagen
    Severity of Illness Index
    Sex Factors
    Spondylitis, Ankylosing

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22462419