Abstract

We describe a patient with dermatomyositis who presented with rapidly developing severe muscle weakness complicated by massive pleural effusion with interstitial lung disease. Myopathological analysis was suggestive of dermatomyositis. This patient showed both anti-Jo-1 and anti-SRP antibodies in serum. To our knowledge, the coexistence of these two myositis-specific autoantibodies (MSA) is considered extremely rare and is clearly an exception to the rule of having only one MSA. Our findings provide compelling evidence that the coexistence of these two MSAs may lead to more severe clinical symptoms, interacting in a complex fashion, thus expanding the clinical spectrum of idiopathic inflammatory myopathy.

Links

Publisher Full Text

Authors

Sugie K, Tonomura Y, Ueno S

Institution

Department of Neurology, Nara Medical University School of Medicine, Japan. ksugie@naramed-u.ac.jp

Source

Internal medicine (Tokyo, Japan) 51:7 2012 pg 799-802

MeSH

Antibodies, Antinuclear
Autoantibodies
Dermatomyositis
Humans
Lung Diseases, Interstitial
Male
Middle Aged
Muscle Weakness
Pleural Effusion
Signal Recognition Particle

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22466843