Abstract

Chronic myeloid leukaemia (CML) affects approximately 560 people annually in the UK. Although median age at diagnosis is 60 years (National Institute for Health and Clinical Excellence (NICE), 2012), CML occurs in all age groups (National Comprehensive Cancer Network (NCCN), 2012). It is a clonal myeloproliferative disorder which is characterized by a reciprocal translocation between chromosomes 9 and 22, resulting in the formation of the Philadelphia chromosome (Ph Chromosome) and the development of an unregulated tyrosine kinase (BCR-ABL) which is responsible for the pathogenesis of CML (NCCN, 2012).

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Authors

Dowling M, Meenaghan T, Kelly M

Institution

School of Nursing and Midwifery National University of Ireland, Galway, Ireland.

Source

British journal of nursing (Mark Allen Publishing) 21:4 pg S16-7

MeSH

Antineoplastic Agents
Great Britain
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Medical Oncology
Oncologic Nursing
Practice Guidelines as Topic

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22470902