Abstract

Endocytic recycling returns proteins to the plasma membrane in many physiological contexts. Studies of these events have helped to elucidate fundamental mechanisms that underlie recycling. Recycling was for some time considered to be the exception to a general mechanism of active cargo sorting in multiple intracellular pathways. In recent years, studies have begun to reconcile this seeming disparity and also suggest explanations for why early recycling studies did not detect active sorting. Further articulation of this emerging trend has far-reaching implications for a deeper understanding of many physiological and pathological events that require recycling.

Links

Publisher Full Text

Authors

Hsu VW, Bai M, Li J

Institution

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachsuetts 02115, USA. vhsu@rics.bwh.harvard.edu

Source

Nature reviews. Molecular cell biology 13:5 2012 May pg 323-8

MeSH

Biological Transport, Active
Cell Polarity
Endocytosis
Endosomes
Humans
Protein Sorting Signals
Protein Transport
Receptors, Transferrin
Vesicular Transport Proteins

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22498832