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Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice.

Abstract

Alcoholic liver disease, which is one of the most serious liver disorders, has been known to cause by ethanol intake. In the present study, in vivo hepatoprotective effects of dieckol-rich phlorotannins (DRP) from Ecklonia cava, a brown seaweed, on ethanol induced hepatic damage in BALB/c mice liver were investigated. After administration of 5 and 25mg/kg mouse of DRP and 4 g/kg mice ethanol, the body weights and survival rates were increased as compared to the control, which is ethanol-treated group without DRP. The glutamic oxaloacetic transaminase and glutamic pyruvic transaminase levels in the serum were lower than those of the control. DRP exhibited a reduction of the total cholesterol. The lower levels of SOD enzyme and a reduction of the formation of malondialdehyde were occurred in mice fed with 5 and 25mg/kg mouse of DRP. Finally the effect on improvement of fatty liver induced by ethanol was observed by taking out the liver immediately after dissecting the mouse. However, no significant difference was observed on hepatic histopathological changes. In conclusion, this study indicated that DRP could protect liver injury induced by ethanol in vivo. It suggested that DRP possesses the beneficial effect to human against ethanol-induced liver injury.

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  • Publisher Full Text
  • Authors

    Kang MC, Ahn G, Yang X, Kim KN, Kang SM, Lee SH, Ko SC, Ko JY, Kim D, Kim YT, Jee Y, Park SJ, Jeon YJ

    Institution

    Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.

    Source

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 50:6 2012 Jun pg 1986-91

    MeSH

    Alanine Transaminase
    Animals
    Aspartate Aminotransferases
    Benzofurans
    Body Weight
    Cholesterol
    Glutathione Peroxidase
    Hepatitis, Alcoholic
    Lipid Peroxidation
    Liver
    Male
    Malondialdehyde
    Mice
    Mice, Inbred BALB C
    Republic of Korea
    Seaweed
    Survival
    Tannins
    Thiobarbituric Acid Reactive Substances

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22504843